Publications

2017


Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges. Poon A, Zhang Y, Chandrasekaran A, Phanthong P, Schmid B, Nielsen TT, Freude KK. New Biotechnology 2017, ahead of print
[ Paper ]

RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts. Xiong K, Zhou Y, Blichfeld KA, Hyttel P, Bolund L, Freude KK, Luo Y. Cellular Reprogramming 2017, 19(3):189-198
[ Paper ]

Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons. Aldana BI, Zhang Y, Lihme MF, Bak LK, Nielsen JE, Holst B, Hyttel P, Freude KK, Waagepetersen HS. Neurochemistry International 2017, 106:48-61
[ Paper ]

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Zhang Y, Schmid B, Nikolaisen NK, Rasmussen MA, Aldana BI, Agger M, Calloe K, Stummann TC, Larsen HM, Nielsen TT, Huang J, Xu F, Liu X, Bolund L, Meyer M, Bak LK, Waagepetersen HS, Luo Y, Nielsen JE, Holst B, Clausen C, Hyttel P, Freude KK. Stem Cell Reports 2017, 8(3):648-658
[ Paper ]

2016


Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Kitiyanant N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Research 2016, 17(3):556-559
[ Paper ]

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Nimsanor N, Jørring I, Rasmussen MA, Clausen C, Mau-Holzmann UA, Kitiyanant N, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Research 2016, 17(3):564-567
[ Paper ]

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Research 2016, 17(3):576-579
[ Paper ]

Generation of an isogenic, gene-corrected iPSC line from a pre-symptomatic 28-year-old woman with an R406W mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Research 2016, 17(3):600-602
[ Paper ]

Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency. Zhou Y, Al-Saaidi RA, Fernandez-Guerra P, Freude KK, Olsen RKJ, Jensen UB, Gregersen N, Hyttel P, Bolund L, Aagaard L, Bross P, Luo Y. Stem Cells and Development 2017, 26(3):166-176
[ Paper ]

Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM). Xiong K, Zhou Y, Hyttel P, Bolund L, Freude KK, Luo Y. Stem Cell Research 2016, 17(3):665-669
[ Paper ]

Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Hansen SK, Stummann TC, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Daechsel JC, Fog K, Hyttel P. Stem Cell Research 2016, 17(2):306-317
[ Paper ]

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1. Poon A, Li T, Pires C, Nielsen TT, Nielsen JE, Holst B, Dinnyes A, Hyttel P, Freude KK. Stem Cell Research 2016, 17(3):470-473
[ Paper ]

Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Poon A, Schmid B, Pires C, Nielsen TT, Hjermind LE, Nielsen JE, Holst B, Hyttel P, Freude KK. Stem Cell Research 2016, 17(3):466-469
[ Paper ]

Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Hall VJ, Lindblad MM, Jakobsen JE, Gunnarsson A, Schmidt M, Rasmussen MA, Volke D, Zuchner T, Hyttel P. Disease Models & Mechanisms 2015, 8(10):1265-1278
[ Paper ]

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1. Pires C, Schmid B, Petræus C, Poon A, Nimsanor N, Nielsen TT, Waldemar G, Hjermind LE, Nielsen JE, Hyttel P, Freude KK. Stem Cell Research 2016, 17(2):285-288
[ Paper ]

Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11. Hansen SK, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Stummann TC, Fog K, Hyttel P. Stem Cell Research 2016, 16(3):553-556
[ Paper ]

Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11. Hansen SK, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Stummann TC, Fog K, Hyttel P. Stem Cell Research 2016, 16(3):589-592
[ Paper ]

The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF. Zhou S, Ochalek A, Szczesna K, Avci HX, Kobolák J, Varga E, Rasmussen M, Holst B, Cirera S, Hyttel P, Freude KK, Dinnyés A. Differentiation 2016, 92(4):183-194
[ Paper ]

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Zhang Y, Schmid B, Nielsen TT, Nielsen JE, Clausen C, Hyttel P, Holst B, Freude KK. Stem Cell Research 2016, 17(1):151-153
[ Paper ]

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Zhang Y, Schmid B, Nielsen TT, Nielsen JE, Clausen C, Hyttel P, Holst B, Freude KK. Stem Cell Research 2016, 17(1):148-150
[ Paper ]

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1. Tubsuwan A, Pires C, Rasmussen MA, Schmid B, Nielsen JE, Hjermind LE, Hall V, Nielsen TT, Waldemar G, Hyttel P, Clausen C, Kitiyanant N, Freude KK, Holst B. Stem Cell Research 2016, 16(1):110-112
[ Paper ]

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1. Li T, Pires C, Nielsen TT, Waldemar G, Hjermind LE, Nielsen JE, Dinnyes A, Hyttel P, Freude KK. Stem Cell Research 2016, 16(2):229-232
[ Paper ]

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1. Li T, Pires C, Nielsen TT, Waldemar G, Hjermind LE, Nielsen JE, Dinnyes A, Holst B, Hyttel P, Freude KK. Stem Cell Research 2016, 16(2):334-337
[ Paper ]

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266. Marthaler AG, Tubsuwan A, Schmid B, Poulsen UB, Engelbrecht AF, Mau-Holzmann UA, Hyttel P, Nielsen TT, Nielsen JE, Holst B. Stem Cell Research 2016, 16(1):202-205
[ Paper ]

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196. Marthaler AG, Schmid B, Tubsuwan A, Poulsen UB, Hyttel P, Nielsen TT, Nielsen JE, Holst B. Stem Cell Research 2016, 16(1):199-201
[ Paper ]

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271. Marthaler AG, Schmid B, Tubsuwan A, Poulsen UB, Engelbrecht AF, Mau-Holzmann UA, Hyttel P, Nielsen JE, Nielsen TT, Holst B. Stem Cell Research 2016, 16(1):180-183
[ Paper ]

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266. Marthaler AG, Schmid B, Tubsuwan A, Poulsen UB, Hyttel P, Nielsen TT, Nielsen JE, Holst B. Stem Cell Research 2016, 16(1):166-169
[ Paper ]

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196. Marthaler AG, Schmid B, Tubsuwan A, Poulsen UB, Engelbrecht AF, Mau-Holzmann UA, Hyttel P, Nielsen JE, Nielsen TT, Holst B. Stem Cell Research 2016, 16(1):162-165
[ Paper ]

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271. Marthaler AG, Tubsuwan A, Schmid B, Poulsen UB, Hyttel P, Nielsen JE, Nielsen TT, Holst B. Stem Cell Research 2016, 16(1):159-161
[ Paper ]

Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. Rasmussen MA, Hjermind LE, Hasholt LF, Waldemar G, Nielsen JE, Clausen C, Hyttel P, Holst B. Stem Cell Research 2016, 16(1):105-109
[ Paper ]

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Zhou S, Szczesna K, Ochalek A, Kobolák J, Varga E, Nemes C, Chandrasekaran A, Rasmussen M, Cirera S, Hyttel P, Dinnyés A, Freude KK, Avci HX. Stem Cells International 2016, 2016:1-15
[ PubMed | Paper ]

Books, Book Chapters


Human Induced Pluripotent Stem Cells and their Derivatives for Disease Modeling and Therapeutic Applications in Alzheimer’s Disease
Pires C, Hall , Freude KK. In Alzheimer's Disease. , SMgroup 2016
[ Chapter ]

2015


Genetically modified pig models for neurodegenerative disorders. Holm IE, Alstrup AKO, Luo Y. The Journal of Pathology 2015, 238(2):267-287
[ PubMed | Paper ]

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models. Djelloul M, Holmqvist S, Boza-Serrano A, Azevedo C, Yeung M, Goldwurm S, Frisén J, Deierborg T, Roybon L. Stem Cell Reports 2015, 5(2):174-184
[ PubMed | Paper ]